RapamycinFungusV1, Main, Exploration, bibRecord, 000813

Induction of autophagy by phosphate starvation in an Atg11-dependent manner in Saccharomyces cerevisiae.

Identifieur interne : 000813 ( Main/Exploration ); précédent : 000812; suivant : 000814

Induction of autophagy by phosphate starvation in an Atg11-dependent manner in Saccharomyces cerevisiae.

Auteurs : Hiroto Yokota [Japon] ; Katsuya Gomi [Japon] ; Takahiro Shintani [Japon]

Source :

Biochemical and biophysical research communications [ 1090-2104 ] ; 2017.

RBID : pubmed:28013049

Descripteurs français

English descriptors

KwdEn :
- Adaptor Proteins, Signal Transducing (genetics), Adaptor Proteins, Signal Transducing (metabolism), Autophagy (MeSH), Autophagy-Related Proteins (genetics), Autophagy-Related Proteins (metabolism), Kinetics (MeSH), Nitrogen (chemistry), Phosphates (chemistry), Phosphorylation (MeSH), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (physiology), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (MeSH), Transcription Factors (genetics), Transcription Factors (metabolism), Vesicular Transport Proteins (genetics), Vesicular Transport Proteins (metabolism).
MESH :
- chemical , chemistry : Nitrogen, Phosphates.
- chemical , genetics : Adaptor Proteins, Signal Transducing, Autophagy-Related Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors, Vesicular Transport Proteins.
- chemical , metabolism : Adaptor Proteins, Signal Transducing, Autophagy-Related Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors, Vesicular Transport Proteins.
- genetics : Saccharomyces cerevisiae.
- physiology : Saccharomyces cerevisiae.
- Autophagy, Kinetics, Phosphorylation, Signal Transduction.

Abstract

Upon nutrient starvation, eukaryotic cells exploit autophagy to reconstruct cellular components. Although autophagy is induced by depletion of various nutrients such as nitrogen, carbon, amino acids, and sulfur in yeast, it was previously ambiguous whether phosphate depletion could trigger the induction of autophagy. Here, we showed that phosphate depletion induced autophagy in Saccharomyces cerevisiae, albeit to a lesser extent than nitrogen starvation. It is known that rapid inactivation of the target of rapamycin complex 1 (TORC1) signaling pathway contributes to Atg13 dephosphorylation, which is one of the cues for autophagy induction. We found that phosphate starvation caused Atg13 dephosphorylation with slower kinetics than nitrogen starvation, suggesting that poor autophagic activity during phosphate starvation was associated with slower inactivation of the TORC1 pathway. Phosphate starvation-induced autophagy requires Atg11, an adaptor protein for selective autophagy, but not its cargo recognition domain. These results suggested that Atg11 plays important roles in low-level nonselective autophagy.

DOI: 10.1016/j.bbrc.2016.12.112
PubMed: 28013049

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Autophagy-Related Proteins (genetics)</term>
<term>Autophagy-Related Proteins (metabolism)</term>
<term>Kinetics (MeSH)</term>
<term>Nitrogen (chemistry)</term>
<term>Phosphates (chemistry)</term>
<term>Phosphorylation (MeSH)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (physiology)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
<term>Vesicular Transport Proteins (genetics)</term>
<term>Vesicular Transport Proteins (metabolism)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie (MeSH)</term>
<term>Azote (composition chimique)</term>
<term>Cinétique (MeSH)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Phosphates (composition chimique)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protéines adaptatrices de la transduction du signal (génétique)</term>
<term>Protéines adaptatrices de la transduction du signal (métabolisme)</term>
<term>Protéines associées à l'autophagie (génétique)</term>
<term>Protéines associées à l'autophagie (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Protéines du transport vésiculaire (génétique)</term>
<term>Protéines du transport vésiculaire (métabolisme)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (physiologie)</term>
<term>Transduction du signal (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Nitrogen</term>
<term>Phosphates</term>
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<term>Autophagy-Related Proteins</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
<term>Vesicular Transport Proteins</term>
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<term>Phosphates</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines associées à l'autophagie</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines du transport vésiculaire</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines associées à l'autophagie</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines du transport vésiculaire</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Autophagy</term>
<term>Kinetics</term>
<term>Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Autophagie</term>
<term>Cinétique</term>
<term>Phosphorylation</term>
<term>Transduction du signal</term>
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<front><div type="abstract" xml:lang="en">Upon nutrient starvation, eukaryotic cells exploit autophagy to reconstruct cellular components. Although autophagy is induced by depletion of various nutrients such as nitrogen, carbon, amino acids, and sulfur in yeast, it was previously ambiguous whether phosphate depletion could trigger the induction of autophagy. Here, we showed that phosphate depletion induced autophagy in Saccharomyces cerevisiae, albeit to a lesser extent than nitrogen starvation. It is known that rapid inactivation of the target of rapamycin complex 1 (TORC1) signaling pathway contributes to Atg13 dephosphorylation, which is one of the cues for autophagy induction. We found that phosphate starvation caused Atg13 dephosphorylation with slower kinetics than nitrogen starvation, suggesting that poor autophagic activity during phosphate starvation was associated with slower inactivation of the TORC1 pathway. Phosphate starvation-induced autophagy requires Atg11, an adaptor protein for selective autophagy, but not its cargo recognition domain. These results suggested that Atg11 plays important roles in low-level nonselective autophagy.</div>
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Induction of autophagy by phosphate starvation in an Atg11-dependent manner in Saccharomyces cerevisiae.

Induction of autophagy by phosphate starvation in an Atg11-dependent manner in Saccharomyces cerevisiae.

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